** ** ** ** ******* ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** **** ********* ** ** ******** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ******* ******* *** **Therefore, as P2P meth spread nationwide, an unparalleled occasion took place in American drug use: Opioid addicts started to change, en masse, to